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These H bonding interactions are critical for high binding affinity. Slight structural modifications can change the ligand from AR antagonist to agonist. Favorable hydrogen bonding between ligand and the T877 side chain, structural features that mimic the 3-keto group of testosterone, and hydrophobic interactions are critical for the ligand to bind with high affinity and stimulate AR action, intel pharma sarms. In another embodiment, the B ring is a 6 membered saturated heterocyclic ring, which may be unsubstituted, monosubstituted or polysubstituted by any of the substitutents described hereinabove, intel pharma sarms.
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