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The use of high dosages of corticosteroids in the treatment of giant cell arteritis is based on the need to suppress vascular inflammation and decrease the risk of blindness, which can happen to someone with the disease," said Professor Andrew Loo, director of the Centre for Molecular Medicine at Imperial College London.
However, the team said the combination of long-term corticosteroid therapy and an anti-inflammatory drug called interleukin-28 (IL-28) could also help reduce the risk of blindness from cataracts and other vascular anomalies, best steroid cycle to gain muscle and lose fat.
The group tested IL-28 and corticosteroids at dosages of 2,500 IU per week for six weeks in five patients each, in their initial attempt to make a causal link between the treatment and the eye disease, best steroid cycle no hair loss. They have now carried out a phase-III trial with the aim of expanding the scope of their research and looking for a better way of achieving this, best steroid cycle workout.
Their research builds on the discovery that the anti-inflammatory IL-28 might be linked to prevention of the development of cataract, by blocking the inflammatory reaction.
The study looked at the potential of combining a drug called tetracycline, which suppresses macrophage infiltration, with an anti-inflammatory drug called interleukin-28, best steroid cycle for quick mass.
"Tetracyclines are a good combination as they are able to fight both the inflammatory response and the cataract, so it's an interesting way to treat this," said Dr Matt Gartner, another co-author of the study, giant cell arteritis treatment uptodate.
"But we were struck by the effect of IL-28 because it didn't seem to come through as anti-inflammatory per se. It was like there had been a lot less macrophage inflammation, and more activation of a cellular anti-inflammatory pathway, best steroid cycle to bulk. This was counterintuitive, as you would think that inflammatory response would be less."
The team found IL-28 suppressed the inflammation of macrophage infiltration - which results in thickening of the blood vessels in the eye - and increased production of a protein called interleukin-6 (IL-6); this produced cataracts, cell uptodate treatment arteritis giant. However, the anti-inflammatory nature of IL-28 made it impossible to prevent cataracts.
"The key difference between the two anti-inflammatory drugs is that one suppresses the inflammatory response while the other inhibits the response," said co-author Dr Peter Ochum, of the British Association for Cataract and Refractive Orthodontics, best steroid cycle to gain muscle mass.
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